OpenAI 等用 1,946 个 GPT-Rosalind-5.5 智能体解读全脑 CRISPR 图谱

AI 导读

OpenAI、PerturbAI 与 Scripps Research 让 1,946 个 GPT-Rosalind-5.5 智能体在 32 分钟内完成全脑小鼠 CRISPR 图谱解读，产出脑部疾病研究的候选线索排序。

推荐理由

这项研究展示了将大型实验拆解给多个智能体并行分析的路径，并给出与人工评审对照的结果。

正文 · 原文

OpenAI showed that AI agents can handle the slowest step in modern biology, making sense of huge experiments.

By splitting a huge brain experiment among 1,946 AI agents, OpenAI got in 32 minutes what it estimates would take people months: a ranked list of leads for new brain-disease research.

So biology labs can now produce experiments far bigger than their own experts can fully interpret

OpenAI, PerturbAI and Scripps Research had 1,946 GPT-Rosalind-5.5 agents interpret a whole-brain mouse CRISPR atlas in 32 minutes.

Each agent analyzed a single knockout’s effects and searched the literature, without seeing the atlas paper, which appeared after the model’s December 2025 knowledge cutoff.

They still matched or refined 48 of the 55 published findings the expression data could support.

The main advance is the method: split 1 giant analysis into nearly 2K small ones, 1 gene per agent, and run them all at once. A single agent given 893 genes cited just 11 papers, while the split-up agents cited 711 times as many, and blinded PhD reviewers preferred their reports 75% of the time.