Google DeepMind 开源 AlphaProtein Novo 酶从头设计流水线
Google DeepMind 介绍 AlphaProtein Novo（AP Novo），一条用于酶从头设计的流水线，与 Frances Arnold 的团队合作开发，在 2 个基准反应上取得 SoTA 的 novel-scaffold 活性，并设计出合成药物片段 piperidine 和降解环境毒素 DEHP 的酶。
Introducing AlphaProtein Novo, a pipeline for de novo enzyme design! In collaboration with @francesarnold's group, we developed AP Novo and used it to get SoTA "novel-scaffold" activity on 2 benchmark reactions and create enzymes to synthesize the pharmaceutical motif piperidine and degrade the environmental toxin DEHP.
Work led by @ZvxyWu @ZiqiLi0513 with teammates @alexechu_ @kelly_ruijie @schulluc @jacobjinkelly @rosaliags @davidla @solserpens @j_reisenbauer, @pengliu_group, Josh, Thomas, Amy, Tristan, Harshnira, and others. It was a joy and privilege to work with you all!
Preprints and code:
biorxiv.org/content/10.64898…
biorxiv.org/content/10.64898…
github.com/google-deepmind/a…
来源：jueseph · x.com